Abstract Laron Syndrome (LS)[OMIm# 262500], or primary GH insensitivity, was first
described in 1966 in consanguineous Jewish families from Yemen. LS is characterized by a …

Objective: To describe the characteristics of untreated and recombinant insulin-like growth
factor 1 (IGF-1)-treated patients with the Laron syndrome (LS) as seen in our clinic over a …

Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by
dwarfism and obesity, and is caused by deletion or mutations of the growth hormone …

Growth hormone (GH) promotes body growth by binding with two GH receptors (GHRs) at
the cell surface. GHRs interact with Janus kinase, signal transducers, and transcription …

Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the
growth hormone receptor (GH-R) gene and is typically associated with dwarfism and …

Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital
insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS …

Many clinical and experimental studies have implicated the growth hormone (GH)–insulin-
like growth factor (IGF-1) axis with the progression of cancer. The epidemiological finding …

Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving
a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS …

Laron syndrome (LS) is a rare, genetic disorder inherited in an autosomal recessive manner.
The disease is caused by mutations of the growth hormone (GH) gene, leading to GH/insulin …

Linear growth during childhood is the result of the synergic contribution of different factors.
The best growth determinant system during each period of life is represented by the growth …