Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

The postsynaptic density (PSD) is a massive protein complex, critical for synaptic strength
and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

Therapies for stroke have remained elusive in the past despite the great relevance of this
pathology. However, recent results have provided strong evidence that postsynaptic density …

Globular PDZ domains typically serve as protein–protein interaction modules that regulate a
wide variety of cellular functions via recognition of short linear motifs (SLiMs). Often, PDZ …

Abstract Post-synaptic density-95, disks-large and zonula occludens-1 (PDZ) domains are
small globular protein–protein interaction domains widely conserved from yeast to humans …

Plant innate immunity is tightly regulated. The Arabidopsis thaliana CALCIUM‐DEPENDENT
PROTEIN KINASE28 (CPK28) functions as a negative immune regulator. We recently …

Calcium (Ca2+)-dependent protein kinases (CDPKs or CPKs) are a unique family of Ca2+
sensor/kinase-effector proteins with diverse functions in plants. In Arabidopsis thaliana …