The oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and
trofosfamide represent an important group of therapeutic agents due to their substantial …

The oxazaphosphorine cyclophosphamide (CPA) and ifosfamide (IFO) are two commonly
used DNAalkylating agents in cancer chemotherapy. This review highlights the …

Topotecan (TPT) is a semisynthetic water-soluble derivative of camptothecin (CPT) used as
second-line therapy in patients with metastatic ovarian carcinoma, small cell lung cancer …

Topoisomerase-1 is a key sub-cellular target for anti-cancer therapy. This intranuclear
enzyme, responsible for DNA replication and repair, undergoes interaction with …

The prognosis of patients with CNS involvement of solid tumors is poor. In these patients,
systemic chemotherapy has a theoretical advantage of concurrent treatment of systemic …

A number of second line treatments have been proposed in patients with advanced
pretreated non-small cell lung cancer (NSCLC). However, either single agents or two or …

Ovarian cancer is one of the most lethal gynecologic malignancies in women. By the time
the disease is detected, it will often have metastasized, making treatment more difficult. In …

La rechute ou la récidive d'un cancer de l'ovaire se traduit par une ou des masses tumorales
cliniques et/ou radiologiques avec ou sans symptômes (douleurs, occlusion intestinale…) …