Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Ageing is the largest risk factor for age-related macular degeneration (AMD), and soft drusen
and basal linear deposits are lipid-rich extracellular lesions specific to AMD. Oil red O …

Historically understudied, cholesterol in the retina is receiving more attention now because
of genetic studies showing that several cholesterol-related genes are risk factors for age …

PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Aims/hypothesis Homo sapiens evolved under conditions of intermittent food availability and
prolonged fasting between meals. Periods of fasting are important for recovery from meal …

Purpose Genetic and epidemiologic studies have shown that lipid genes and high-density
lipoproteins (HDLs) are implicated in age-related macular degeneration (AMD). We studied …

The accumulation of lipids within drusen, the epidemiologic link of a high fat diet, and the
identification of polymorphisms in genes involved in lipid metabolism that are associated …