Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Brain-derived neurotrophic factor (BDNF) has been found to play roles in many types of
plasticity including drug addiction. Here, we focus on rodent studies over the past two …

Previous rodent studies have implicated the infralimbic (IL) subregion of the medial
prefrontal cortex in extinction of auditory fear conditioning. However, these studies used …

Epigenetic remodeling contributes to synaptic plasticity via modification of gene expression,
which underlies cocaine-induced long-term memory. A prevailing hypothesis in drug …

Appropriate growth and synaptic integration of GABAergic inhibitory interneurons are
essential for functional neural circuits in the brain. Here, we demonstrate that disruption of …

This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation
(rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze …

Role of brain-derived neurotrophic factor (BDNF)-TrkB signaling in a learned helplessness
(LH) model of depression was investigated. LH rats showed a reduction of BDNF in the …

Stress alters both cognitive and emotional function, and increases risk for a variety of
psychological disorders, such as depression and posttraumatic stress disorder. The …

Flavonoids have long been known to exert benefits in various health problems. Among
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …

Many abused drugs lead to changes in endogenous brain-derived neurotrophic factor
(BDNF) expression in neural circuits responsible for addictive behaviors. BDNF is a known …