Heart failure is a major cause of death and disability. Impairments in blood circulation that
accompany heart failure can be traced, in part, to alterations in the activity of the …

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Diabetic cardiomyopathy is characterized by impaired cardiac contractility leading to poor
myocardial performance. We investigated the role that the hexosamine pathway, and …

Increases in type 1 phosphatase (PP1) activity have been observed in end stage human
heart failure, but the role of this enzyme in cardiac function is unknown. To elucidate the …

Gene therapy is proving likely to be a viable alternative to conventional therapies in
coronary artery disease and heart failure. Phase 1 clinical trials indicate high levels of safety …

To examine whether excessive protein O-GlcNAcylation plays a role in the dysfunction of the
diabetic heart, we delivered adenovirus expressing O-GlcNAcase (Adv-GCA) into the …

Introduction phorylation of its inhibitor protein. 11, 12 In SDS polyacrylamide gels, PLB
migrates pre-The sarcoplasmic reticulum (SR) is an intracellular membranous network …

PKA phosphorylates multiple molecules involved in calcium (Ca2+) handling in cardiac
myocytes and is considered to be the predominant regulator of β-adrenergic receptor …

Heart failure (HF) is a major health problem in Western countries. Despite significant
progress in pharmacological and device-based treatment, the disease burden imposed …

Ablation or inhibition of phospholamban (PLN) has favorable effects in several genetic
murine dilated cardiomyopathies, and we showed previously that a pseudophosphorylated …