[HTML][HTML] Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis

IP Trougakos, E Terpos, H Alexopoulos… - Trends in molecular …, 2022‏ - cell.com
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19)
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …

Quality by Design for enabling RNA platform production processes

S Daniel, Z Kis, C Kontoravdi, N Shah - Trends in biotechnology, 2022‏ - cell.com
RNA-based products have emerged as one of the most promising and strategic
technologies for global vaccination, infectious disease control, and future therapy …

Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis

A Barmada, J Klein, A Ramaswamy, NN Brodsky… - Science …, 2023‏ - science.org
Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including
after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular …

Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection

F Gao, V Mallajosyula, PS Arunachalam… - Immunity, 2023‏ - cell.com
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …

[HTML][HTML] Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study

X Zhu, KA Gebo, AG Abraham, F Habtehyimer… - The Lancet …, 2023‏ - thelancet.com
Background Cytokines and chemokines play a critical role in the response to infection and
vaccination. We aimed to assess the longitudinal association of COVID-19 vaccination with …

[HTML][HTML] Engineering LNPs with polysarcosine lipids for mRNA delivery

DD Kang, X Hou, L Wang, Y Xue, H Li, Y Zhong… - Bioactive Materials, 2024‏ - Elsevier
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-
2 virus, there has been an increased interest in the delivery of mRNA through LNPs …

SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity

JR Jaycox, C Lucas, I Yildirim, Y Dai, EY Wang… - Nature …, 2023‏ - nature.com
Abstract mRNA-based vaccines dramatically reduce the occurrence and severity of COVID-
19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled …

Effect of COVID-19 vaccination on the timing and flow of menstrual periods in two cohorts

A Alvergne, EV Woon, V Male - Frontiers in reproductive health, 2022‏ - frontiersin.org
COVID-19 vaccination protects against the potentially serious consequences of SARS-CoV-
2 infection, but some people have been hesitant to receive the vaccine because of reports …

A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines

FJ Ryan, TS Norton, C McCafferty, SJ Blake… - Cell Reports …, 2023‏ - cell.com
Identifying the molecular mechanisms that promote optimal immune responses to
coronavirus disease 2019 (COVID-19) vaccination is critical for future rational vaccine …

COVID-19 mRNA vaccines: the molecular basis of some adverse events

G Giannotta, A Murrone, N Giannotta - Vaccines, 2023‏ - mdpi.com
Each injection of any known vaccine results in a strong expression of pro-inflammatory
cytokines. This is the result of the innate immune system activation, without which no …