Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …

A large body of evidence has implicated Aβ peptides and other derivatives of the amyloid
precursor protein (APP) as central to the pathogenesis of Alzheimer's disease (AD) …

▪ Abstract During the past decade, the molecular mechanisms underlying the mammalian
circadian clock have been defined. A core set of circadian clock genes common to most cells …

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive hearing impairment leads to social isolation and is also associated with …

Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …

Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

Site-specific recombinase systems (Cre-loxP, Flp-FRT, and φC31-att) are transforming both
forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be …

Mouse genetic manipulation has provided an excellent system to characterize gene function
in numerous contexts. A number of mutants have been produced by using transgenic, gene …

One of the most effective approaches for determining gene function involves engineering
mice with mutations or deletions in endogenous genes of interest. Historically, this approach …