Since the realization that immature myeloid cells are powerful modulators of the immune
response, many studies on “myeloid-derived suppressor cells”(MDSCs) have documented …

Tumor cell–derived extracellular vesicles (EV) convert normal myeloid cells into myeloid-
derived suppressor cells (MDSC), inhibiting antitumor immune responses. Here, we show …

Therapeutic approaches that engage immune cells to treat cancer are becoming
increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid …

Background Tumor cells modulate host immunity by secreting extracellular vesicles (EV)
and soluble factors. Their interactions with myeloid cells lead to the generation of myeloid …

The interest of extracellular vesicles (EVs) in cancer immunotherapy is increasing every day.
EVs are lipid bilayer vesicles released by most cells, which contain the molecular signature …

Skin melanomas are malignant neoplasms originating from neuroectodermal melanocytes.
Compared to other neoplasms, melanomas have a high rate of growth. Their incidence is …

Although KIF4A has been found to play an important role in a variety of tumors and is closely
associated with the activation of immunocytes, its role in bladder cancer (BC) remains …

A negative correlation exists between environmental temperature and cancer risk based on
both epidemiological and statistical analyses. Previously, cold stress was reported to be an …

Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of
oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17 …

Tumor microenvironment (TME) is a complex milieu in which tumor grows, develops and
progresses through a complex bi-directional cross-talk with immune-, stromal cells, and the …