[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
JAK-STAT pathway inhibition and their implications in COVID-19 therapy
S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …
Baricitinib restrains the immune dysregulation in patients with severe COVID-19
BACKGROUND Patients with coronavirus disease 2019 (COVID-19) develop pneumonia
generally associated with lymphopenia and a severe inflammatory response due to …
generally associated with lymphopenia and a severe inflammatory response due to …
The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …
Sex drives dimorphic immune responses to viral infections
New attention to sexual dimorphism in normal mammalian physiology and disease has
uncovered a previously unappreciated breadth of mechanisms by which females and males …
uncovered a previously unappreciated breadth of mechanisms by which females and males …
The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?
An analysis of published data appertaining to the cytokine storms of COVID-19, H1N1
influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) …
influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) …
Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways
Recently an outbreak that emerged in Wuhan, China in December 2019, spread to the
whole world in a short time and killed> 1,410,000 people. It was determined that a new type …
whole world in a short time and killed> 1,410,000 people. It was determined that a new type …
Interplay between Janus kinase/signal transducer and activator of transcription signaling activated by type I interferons and viral antagonism
Y Nan, C Wu, YJ Zhang - Frontiers in immunology, 2017 - frontiersin.org
Interferons (IFNs), which were discovered a half century ago, are a group of secreted
proteins that play key roles in innate immunity against viral infection. The major signaling …
proteins that play key roles in innate immunity against viral infection. The major signaling …
Fine-tuning of type I interferon response by STAT3
Type I interferon (IFN-I) is induced during innate immune response and is required for
initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and …
initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and …
[HTML][HTML] PDIA3: Structure, functions and its potential role in viral infections
The catalysis of disulphide (single bondSsingle bondSsingle bond) bonds is the most
important characteristic of protein disulphide isomerase (PDI) family. Catalysis occurs in the …
important characteristic of protein disulphide isomerase (PDI) family. Catalysis occurs in the …