Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐
mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial …

Bacterial resistance to the antibiotics develops rapidly and is increasingly serious health
concern in the world. It is an insoluble topic due to the multiple resistant mechanisms. The …

Antibiotics have gained increasing attention as pharmaceuticals widely existing in human
society. Under low temperature conditions, antibiotics tend to have higher environmental …

Occurrence, distribution, and ecological risk of 21 pharmaceuticals in the Jilin Songhua
River were investigated during its freeze–thaw periods, including ice formation, sealed, and …

Florfenicol is a member of the phenicol group, a broad-spectrum antibacterial agent. It has
been used for a long time in veterinary medicine, but there are some factors regarding its …

Tilmicosin is a semi-synthetic macrolide for veterinary use with strong antibacterial effect on
respiratory bacteria. In this study, the pharmacokinetic/pharmacodynamic (PK/PD) …

The PK/PD cut-off (PK/PDCO) value of florfenicol for calf pathogens was determined for long
acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of …

Formulating a therapeutic strategy that can effectively combat concurrent infections of
Actinobacillus pleuropneumoniae (A. pleuropneumoniae) and Pasteurella multocida (P …

A major problem of our time is the ever-increasing resistance to antimicrobial agents in
bacterial populations. One of the most effective ways to prevent these problems is to target …

Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in
bacterial resistance, clinical treatment failure, and drug residues. To address these …