Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
Epigenetic regulation of the innate immune response to infection
Q Zhang, X Cao - Nature Reviews Immunology, 2019 - nature.com
Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …
innate immune responses against infection. These pathways are tightly regulated at different …
Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of
infected cells as a stable episome organized into minichromosomes by histones and non …
infected cells as a stable episome organized into minichromosomes by histones and non …
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
E Hervouet, P Peixoto, R Delage-Mourroux… - Clinical …, 2018 - Springer
Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
Genomic medicine and implications for hepatocellular carcinoma prevention and therapy
The pathogenesis of hepatocellular carcinoma (HCC) is poorly understood, but recent
advances in genomics have increased our understanding of the mechanisms by which …
advances in genomics have increased our understanding of the mechanisms by which …
[PDF][PDF] Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B
Hepatitis B virus (HBV) infection represents a significant public health burden worldwide.
Although current therapeutics manage to control the disease progression, lifelong treatment …
Although current therapeutics manage to control the disease progression, lifelong treatment …
[PDF][PDF] Down‐regulated microRNA‐152 induces aberrant DNA methylation in hepatitis B virus–related hepatocellular carcinoma by targeting DNA methyltransferase 1
J Huang, Y Wang, Y Guo, S Sun - Hepatology, 2010 - Wiley Online Library
The hepatitis B virus (HBV) X protein has been implicated as a potential trigger of the
epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying …
epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying …
Hepatitis B virus x protein in the pathogenesis of hepatitis B virus‐induced hepatocellular carcinoma
MC Kew - Journal of gastroenterology and hepatology, 2011 - Wiley Online Library
Currently available evidence supports a role for the hepatitis B virus (HBV) x gene and
protein in the pathogenesis of HBV‐induced hepatocellular carcinoma (HCC). HBx gene is …
protein in the pathogenesis of HBV‐induced hepatocellular carcinoma (HCC). HBx gene is …
HBV induced hepatocellular carcinoma and related potential immunotherapy
Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor
in the initiation and development of hepatocellular carcinoma (HCC), contributing to over …
in the initiation and development of hepatocellular carcinoma (HCC), contributing to over …