The RTK interactome: overview and perspective on RTK heterointeractions
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
Fluorescence-Based Detection of Proteins and Their Interactions in Live Cells
Recent advances in fluorescence-based microscopy techniques, such as single molecule
fluorescence, Förster resonance energy transfer (FRET), fluorescence intensity fluctuations …
fluorescence, Förster resonance energy transfer (FRET), fluorescence intensity fluctuations …
How IGF-1 activates its receptor
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of
normal and neoplastic cells. A ligand-dependent conformational change is thought to …
normal and neoplastic cells. A ligand-dependent conformational change is thought to …
Mechanical disruption of E-cadherin complexes with epidermal growth factor receptor actuates growth factor–dependent signaling
Increased intercellular tension is associated with enhanced cell proliferation and tissue
growth. Here, we present evidence for a force-transduction mechanism that links mechanical …
growth. Here, we present evidence for a force-transduction mechanism that links mechanical …
The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands
The sigma-1 receptor (S1R) is a 223-amino-acid membrane protein that resides in the
endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is …
endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is …
FRET microscopy in 2010: the legacy of Theodor Förster on the 100th anniversary of his birth
The impact of great scientific insights can very often only be measured decades later.
Theodor Fçrster's theory of Fçrster (or fluorescence) resonance energy transfer (FRET) is …
Theodor Fçrster's theory of Fçrster (or fluorescence) resonance energy transfer (FRET) is …
The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures
The EphA2 receptor tyrosine kinase is capable of activating multiple diverse signaling
pathways with roles in processes such as tissue homeostasis and cancer. EphA2 is known …
pathways with roles in processes such as tissue homeostasis and cancer. EphA2 is known …
A general method to quantify ligand-driven oligomerization from fluorescence-based images
Here, we introduce fluorescence intensity fluctuation spectrometry for determining the
identity, abundance and stability of protein oligomers. This approach was tested on …
identity, abundance and stability of protein oligomers. This approach was tested on …
Förster resonance energy transfer microscopy and spectroscopy for localizing protein–protein interactions in living cells
Y Sun, C Rombola, V Jyothikumar… - Cytometry Part …, 2013 - Wiley Online Library
The fundamental theory of Förster resonance energy transfer (FRET) was established in the
1940s. Its great power was only realized in the past 20 years after different techniques were …
1940s. Its great power was only realized in the past 20 years after different techniques were …
Two SERK receptor-like kinases interact with EMS1 to control anther cell fate determination
Cell signaling pathways mediated by leucine-rich repeat receptor-like kinases (LRR-RLKs)
are essential for plant growth, development, and defense. The EMS1 (EXCESS …
are essential for plant growth, development, and defense. The EMS1 (EXCESS …