Several non-redundant features of the tumour microenvironment facilitate
immunosuppression and limit anticancer immune responses. These include physical …

Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours,,–, but the
cause of this link is unknown. Here we show that tumour cells disrupt methionine …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …

Immune cells' metabolism influences their differentiation and function. Given that a complex
interplay of environmental factors within the tumor microenvironment (TME) can have a …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

The inflammatory response involves the activation of several cell types to fight insults
caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand …