Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …
survival have been modest and, in some examples, less than those of other approved …
Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy
Nutritional metal ions play critical roles in many important immune processes. Hence, the
effective modulation of metal ions may open up new forms of immunotherapy, termed as …
effective modulation of metal ions may open up new forms of immunotherapy, termed as …
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates
antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We …
antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We …
Rethinking cancer nanotheranostics
Advances in nanoparticle synthesis and engineering have produced nanoscale agents
affording both therapeutic and diagnostic functions that are often referred to by the …
affording both therapeutic and diagnostic functions that are often referred to by the …
Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management
Abstract Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines
display a superior advantage because the nasal mucosa is often the initial site of infection …
display a superior advantage because the nasal mucosa is often the initial site of infection …
Vaccine-like nanomedicine for cancer immunotherapy
Y Yi, M Yu, W Li, D Zhu, L Mei, M Ou - Journal of Controlled Release, 2023 - Elsevier
The successful clinical application of immune checkpoint blockade (ICB) and chimeric
antigen receptor T cells (CAR-T) therapeutics has attracted extensive attention to …
antigen receptor T cells (CAR-T) therapeutics has attracted extensive attention to …
Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles
Intravenously administered cyclic dinucleotides and other STING agonists are hampered by
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …
Recent advancements in liposome technology
The liposomes have continued to be well-recognized as an important nano-sized drug
delivery system with attractive properties, such a characteristic bilayer structure assembling …
delivery system with attractive properties, such a characteristic bilayer structure assembling …
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising
class of immunotherapeutics that activate innate immunity to increase tumour …
class of immunotherapeutics that activate innate immunity to increase tumour …