Mucin glycan foraging in the human gut microbiome

LE Tailford, EH Crost, D Kavanaugh, N Juge - Frontiers in genetics, 2015 - frontiersin.org
The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key
role in sha** the structure-function of the microbiota. In particular, some gut bacteria have …

The human gut microbiome: ecology and recent evolutionary changes

J Walter, R Ley - Annual review of microbiology, 2011 - annualreviews.org
The human gastrointestinal tract is divided into sections, allowing digestion and nutrient
absorption in the proximal region to be separate from the vast microbial populations in the …

Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes

ZT Yu, C Chen, DS Newburg - Glycobiology, 2013 - academic.oup.com
Human milk oligosaccharides (HMOS) are not digested in the proximal intestine. In distal
intestine, HMOS collectively modify the microbiota, but the response of individual bacteria to …

Genome-centric investigation of bile acid metabolizing microbiota of dairy cows and associated diet-induced functional implications

L Lin, Z Lai, H Yang, J Zhang, W Qi, F **e… - The ISME …, 2023 - academic.oup.com
Although the importance of bile acid (BA)-related microbial strains and enzymes is
increasingly recognized for monogastric animals, a lack of knowledge about BA metabolism …

Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria

LJ Kiely, K Busca, JA Lane… - FEMS Microbiology …, 2023 - academic.oup.com
A number of bacterial species are found in high abundance in the faeces of healthy breast-
fed infants, an occurrence that is understood to be, at least in part, due to the ability of these …

Biochemical and structural basis of sialic acid utilization by gut microbes

A Bell, E Severi, CD Owen, D Latousakis… - Journal of Biological …, 2023 - ASBMB
The human gastrointestinal (GI) tract harbors diverse microbial communities collectively
known as the gut microbiota that exert a profound impact on human health and disease. The …

Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis

L Rohmer, D Hocquet, SI Miller - Trends in microbiology, 2011 - cell.com
It is interesting to speculate that the evolutionary drive for microbes to develop pathogenic
characteristics was to access the nutrient resources that animals provided. Animal …

Utilisation of Mucin Glycans by the Human Gut Symbiont Ruminococcus gnavus Is Strain-Dependent

EH Crost, LE Tailford, G Le Gall, M Fons, B Henrissat… - PloS one, 2013 - journals.plos.org
Commensal bacteria often have an especially rich source of glycan-degrading enzymes
which allow them to utilize undigested carbohydrates from the food or the host. The species …

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

J Briliūtė, PA Urbanowicz, AS Luis, A Baslé… - Nature …, 2019 - nature.com
Glycans are the major carbon sources available to the human colonic microbiota. Numerous
N-glycosylated proteins are found in the human gut, from both dietary and host sources …

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

A Bell, J Brunt, E Crost, L Vaux, R Nepravishta… - Nature …, 2019 - nature.com
Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is commonly found in the terminal location of
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …