The pulmonary circulation is a high flow and low pressure circuit, with an average resistance
of 1 mmHg. min. L− 1 in young adults, increasing to 2.5 mmHg. min. L− 1 over 4–6 decades …

High-altitude pulmonary edema (HAPE) is an uncommon form of pulmonary edema that
occurs in healthy individuals within a few days of arrival at altitudes above 2,500–3,000 m …

Introduction Acetazolamide (AZM) is used for various conditions (eg, altitude sickness, sleep
apnoea, glaucoma), but therapy is often limited by its side effect profile. Our objective was to …

The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that
helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary …

Carbonic anhydrase (CA) inhibitors, particularly acetazolamide, have been used at high
altitude for decades to prevent or reduce acute mountain sickness (AMS), a syndrome of …

Abstract Naeije, Robert, and Rebecca Vanderpool. Pulmonary hypertension and chronic
mountain sickness. High Alt Med Biol 14: 117–125, 2013.—Chronic mountain sickness is a …

Rationale: Monge's disease is characterized by an excessive erythrocytosis, frequently
associated with pulmonary hypertension, in high-altitude dwellers. It has a considerable …

Doherty, Connor J., Jou-Chung Chang, Benjamin P. Thompson, Erik R. Swenson, Glen E.
Foster, and Paolo B. Dominelli. The impact of acetazolamide and methazolamide on …

Air pollution has recently been associated with the development of acute decompensated
heart failure, but the underlying biological mechanisms remain unclear. A pulmonary …

We tested the effect of acetazolamide on blood mechanical properties and pulmonary
vascular resistance (PVR) during chronic hypoxia. Six groups of rats were either treated or …