Superoxide dismutase 1 in health and disease: how a frontline antioxidant becomes neurotoxic
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …
Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disorder, with a
significant social and economic burden. ALS remains incurable, and the only drugs …
significant social and economic burden. ALS remains incurable, and the only drugs …
[HTML][HTML] Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression
M Kalia, M Miotto, D Ness, S Opie-Martin… - Computational and …, 2023 - Elsevier
Mutations in the superoxide dismutase 1 (SOD1) gene are the second most common known
cause of ALS. SOD1 variants express high phenotypic variability and over 200 have been …
cause of ALS. SOD1 variants express high phenotypic variability and over 200 have been …
Zinc binding loop mutations of hSOD1 promote amyloid fibrils under physiological conditions: Implications for initiation of amyotrophic lateral sclerosis
Neurotoxic species of misfolded hSOD1 are involved in the process of causing amyotrophic
lateral sclerosis (ALS), which is a devastating neurodegenerative disease. Considerable …
lateral sclerosis (ALS), which is a devastating neurodegenerative disease. Considerable …
[HTML][HTML] Amyotrophic lateral sclerosis disease-related mutations disrupt the dimerization of superoxide dismutase 1-A comparative molecular dynamics simulation …
More than 150 genes are involved in amyotrophic lateral sclerosis (ALS), with superoxide
dismutase 1 (SOD1) being one of the most studied. Mutations in SOD1 gene, which encodes …
dismutase 1 (SOD1) being one of the most studied. Mutations in SOD1 gene, which encodes …
[HTML][HTML] Development of in silico analysis and molecular dynamics simulation on L67P and D76Y mutants of the human superoxide dismutase 1 (hSOD1) related to …
P Baziyar, B Seyedalipour… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Background: One neurodegenerative disorder that is caused by a mutation in the hSOD1
gene is Amyotrophic lateral sclerosis (ALS). Objectives: The current study was developed in …
gene is Amyotrophic lateral sclerosis (ALS). Objectives: The current study was developed in …
[HTML][HTML] Yeast proteins may reversibly aggregate like amphiphilic molecules
More than a hundred proteins in yeast reversibly aggregate and phase-separate in
response to various stressors, such as nutrient depletion and heat shock. We know little …
response to various stressors, such as nutrient depletion and heat shock. We know little …
Computer analysis of the relation between hydrogen bond stability in SOD1 mutants and the survival time of amyotrophic lateral sclerosis patients
NA Alemasov, VS Timofeev, NV Ivanisenko… - Journal of Molecular …, 2022 - Elsevier
Background and objective Mutations in the SOD1 protein can lead to the death of motor
neurons, which, in turn, causes an incurable disease called amyotrophic lateral sclerosis …
neurons, which, in turn, causes an incurable disease called amyotrophic lateral sclerosis …
Genomics research at bioinformatics of genome regulation and structure\systems biology (BGRS\SB) conferences in Novosibirsk
Wang and coauthors [21] present method for chromosome structure analysis on cooperation
of transcription factors (TF) based on integration of DNA sequences, ChIP-Seq and ChIA …
of transcription factors (TF) based on integration of DNA sequences, ChIP-Seq and ChIA …
Critical sites of DNA backbone integrity for damaged base removal by formamidopyrimidine–DNA glycosylase
AV Endutkin, DO Zharkov - Biochemistry, 2019 - ACS Publications
DNA glycosylases, the enzymes that initiate base excision DNA repair, recognize damaged
bases through a series of precisely orchestrated movements. Most glycosylases sharply kink …
bases through a series of precisely orchestrated movements. Most glycosylases sharply kink …