Osteosarcoma (OS) is an aggressive bone tumor that mainly affects children and
adolescents. OS has a strong tendency to relapse and metastasize, resulting in poor …

Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate
has not improved significantly in the past 30 years, which brings a heavy burden to patients …

Bone sarcomas are commonly characterized by a high degree of intra-tumor heterogeneity,
which in part is due to the presence of subpopulations of tumor cells presenting stem cell …

Osteosarcoma is the most common primary bone tumor, and its first line of treatment
presents a high failure rate. The 5-year survival for children and teenagers with …

Gene transfection was supposed to be the most promising technology to overcome the vast
majority of diseases and it has been popularly reported in clinical applications of gene …

Currently, although the improvement of surgical techniques and the development of
chemotherapy drugs have brought a certain degree of development to the treatment of …

Osteosarcoma is a highly invasive kind of malignant bone tumor. Exosomes are a type of
extracellular vesicles that play an important role in intercellular communication in the …

It only took 8 months for the pneumonia caused by a previously unknown coronavirus to turn
into a global pandemic of unprecedentedly far-reaching implications. Failure of the already …

Although osteosarcoma is the most common primary malignant bone tumor,
chemotherapeutic drugs and treatment have failed to increase the five-year survival rate …

Resistance to systemic therapies in sarcomas poses a significant challenge to improving
clinical outcomes. Recent research has concentrated on the tumor microenvironment's role …