Holotomography

G Kim, H Hugonnet, K Kim, JH Lee, SS Lee… - Nature Reviews …, 2024 - nature.com
Holotomography (HT) represents a 3D, label-free optical imaging methodology that
leverages refractive index as an inherent quantitative contrast for imaging. This technique …

Quantitative phase imaging for medical diagnosis

H Majeed, S Sridharan, M Mir, L Ma, E Min… - Journal of …, 2017 - Wiley Online Library
Optical microscopy is an indispensable diagnostic tool in modern healthcare. As a prime
example, pathologists rely exclusively on light microscopy to investigate tissue morphology …

Spatial light interference microscopy: principle and applications to biomedicine

X Chen, ME Kandel, G Popescu - Advances in optics and photonics, 2021 - opg.optica.org
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-
shifting interferometer, built onto a phase-contrast microscope, with white-light illumination …

Quantitative phase imaging (QPI) in neuroscience

C Hu, G Popescu - IEEE Journal of Selected Topics in Quantum …, 2018 - ieeexplore.ieee.org
Quantitative phase imaging (QPI) is an emerging label-free modality that attracts significant
interest in biomedicine in general and neuroscience in particular. Based on the principle of …

Label-free optical quantification of structural alterations in Alzheimer's disease

M Lee, E Lee, JH Jung, H Yu, K Kim, J Yoon, S Lee… - Scientific reports, 2016 - nature.com
We present a wide-field quantitative label-free imaging of mouse brain tissue slices with sub-
micrometre resolution, employing holographic microscopy and an automated scanning …

Quantitative phase imaging for label-free analysis of cancer cells—focus on digital holographic microscopy

Z El-Schich, A Leida Mölder, A Gjörloff Wingren - Applied Sciences, 2018 - mdpi.com
To understand complex biological processes, scientists must gain insight into the function of
individual living cells. In contrast to the imaging of fixed cells, where a single snapshot of the …

Complex refractive index of normal and malignant human colorectal tissue in the visible and near‐infrared

P Giannios, S Koutsoumpos… - Journal of …, 2017 - Wiley Online Library
A multi‐wavelength prism coupling refractometer is utilized to measure the angular
reflectance of freshly excised human intestinal tissue specimens. Based on reflectance data …

Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM)

H Majeed, TH Nguyen, ME Kandel, A Kajdacsy-Balla… - Scientific reports, 2018 - nature.com
Breast cancer is the most common type of cancer among women worldwide. The standard
histopathology of breast tissue, the primary means of disease diagnosis, involves manual …

Multimodal quantitative phase imaging with digital holographic microscopy accurately assesses intestinal inflammation and epithelial wound healing

P Lenz, M Brückner, S Ketelhut… - Journal of …, 2016 - pmc.ncbi.nlm.nih.gov
The incidence of inflammatory bowel disease, ie, Crohn's disease and Ulcerative colitis, has
significantly increased over the last decade. The etiology of IBD remains unknown and …

Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging

H Majeed, C Okoro, A Kajdacsy-Balla… - … of biomedical optics, 2017 - spiedigitallibrary.org
Tumor progression in breast cancer is significantly influenced by its interaction with the
surrounding stromal tissue. Specifically, the composition, orientation, and alignment of …