The hypoxia-adenosine link during myocardial ischemia—reperfusion injury
Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …
[HTML][HTML] Adenosine receptor signalling as a driver of pulmonary fibrosis
E Cash, AT Goodwin, AL Tatler - Pharmacology & Therapeutics, 2023 - Elsevier
Pulmonary fibrosis is a debilitating and life-limiting lung condition in which the damage-
response mechanisms of mixed-population cells within the lungs go awry. The tissue …
response mechanisms of mixed-population cells within the lungs go awry. The tissue …
[HTML][HTML] Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling
Previous studies implicate extracellular adenosine signaling in attenuating myocardial
ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by …
ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by …
The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic
stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the …
stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the …
Alternative adenosine receptor activation: the netrin-Adora2b link
During hypoxia or inflammation, extracellular adenosine levels are elevated. Studies using
pharmacologic approaches or genetic animal models pertinent to extracellular adenosine …
pharmacologic approaches or genetic animal models pertinent to extracellular adenosine …
Probiotic-derived ecto-5'-nucleotidase produces anti-Inflammatory adenosine metabolites in Treg-deficient scurfy mice
Y Liu, SA Armbrister, B Okeugo, TW Mills… - Probiotics and …, 2023 - Springer
Abstract Probiotic Limosilactobacillus reuteri DSM 17938 (DSM 17938) prolongs the survival
of Treg-deficient scurfy (SF) mice and reduces multiorgan inflammation by a process …
of Treg-deficient scurfy (SF) mice and reduces multiorgan inflammation by a process …
A2B Adenosine receptor in idiopathic pulmonary fibrosis: pursuing proper pit stop to interfere with disease progression
Purine nucleotides and nucleosides are involved in various human physiological and
pathological mechanisms. The pathological deregulation of purinergic signaling contributes …
pathological mechanisms. The pathological deregulation of purinergic signaling contributes …
Purinergic and adenosinergic signaling in pancreatobiliary diseases
Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue,
adenosine, all have the capacity to modulate cellular signaling pathways. The cellular …
adenosine, all have the capacity to modulate cellular signaling pathways. The cellular …
Genetic determinants of the acute respiratory distress syndrome
E Suarez-Pajes, E Tosco-Herrera… - Journal of Clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that arises
from multiple causes, including sepsis, pneumonia, trauma, and severe coronavirus disease …
from multiple causes, including sepsis, pneumonia, trauma, and severe coronavirus disease …
Hypoxia-adenosine axis as therapeutic targets for acute respiratory distress syndrome
The human respiratory and circulatory systems collaborate intricately to ensure oxygen
delivery to all cells, which is vital for ATP production and maintaining physiological functions …
delivery to all cells, which is vital for ATP production and maintaining physiological functions …