Three new sets of quinazolinones bearing sulfachloropyridazine 4a-f, 6a-i and 8a-i were
designed and synthesized. All the synthesized compounds were screened for their in vitro …

Growing antibiotic resistance is causing a health care crisis, leading to an urgent need for
new antibiotics to tackle serious hospital and community infections. Pleuromutilin, a naturally …

Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate
reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and …

It is well established that the quorum sensing (QS) in Pseudomonas aeruginosa is primarily
responsible for the synthesis and the release of several virulence factors including …

Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …

Background In response to the urgent need for continuous discovery of new anti-proliferative
agents, a new series of quinazoline compounds 5a-r was prepared. Methods As a reference …

Venezuelan and eastern equine encephalitis viruses (VEEV and EEEV, respectively) are
mosquito-borne, neuroinvasive human pathogens for which no FDA-approved therapeutic …

A family of N, N′-diaryl-N ″-(quinolin-8-yl) guanidines were prepared by two methods, and
these guanidines were subjected to Co (II)-catalyzed C–H functionalization/annulation with …

An unprecedented copper and in situ-generated triflic acid relay-promoted four-component
cascade reaction of cyanamides, diaryliodonium triflates, propargylic amines, and H2O was …

A novel and efficient [3+ 2] annulation of 2-substituted aziridines and N-tosyl cyanamides via
a domino regioselective ring-opening/5-exo-dig cyclization procedure has been developed …