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Vascular density and distribution in neocortex
An amazingly wide range of complex behavior emerges from the cerebral cortex. Much of
the information processing that leads to these behaviors is performed in neocortical circuits …
the information processing that leads to these behaviors is performed in neocortical circuits …
The effects of transit time heterogeneity on brain oxygenation during rest and functional activation
The interpretation of regional blood flow and blood oxygenation changes during functional
activation has evolved from the concept of 'neurovascular coupling', and hence the …
activation has evolved from the concept of 'neurovascular coupling', and hence the …
A quantitative model for human neurovascular coupling with translated mechanisms from animals
Neurons regulate the activity of blood vessels through the neurovascular coupling (NVC). A
detailed understanding of the NVC is critical for understanding data from functional imaging …
detailed understanding of the NVC is critical for understanding data from functional imaging …
A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply
Introduction Radiation-induced oxygen depletion in tissue is assumed as a contributor to the
FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in …
FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in …
Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age …
Water exchange rate (Kw) across the blood–brain barrier (BBB) is an important
physiological parameter that may provide new insight into ageing and neurodegenerative …
physiological parameter that may provide new insight into ageing and neurodegenerative …
[HTML][HTML] Parameter quantification for oxygen transport in the human brain
Background and objective: Oxygen is carried to the brain by blood flow through generations
of vessels across a wide range of length scales. This multi-scale nature of blood flow and …
of vessels across a wide range of length scales. This multi-scale nature of blood flow and …
Mathematical methods for modeling the microcirculation
The microcirculation plays a major role in maintaining homeostasis in the body. Alterations
or dysfunctions of the microcirculation can lead to several types of serious diseases. It is not …
or dysfunctions of the microcirculation can lead to several types of serious diseases. It is not …
Improving estimates of the cerebral metabolic rate of oxygen from optical imaging data
The cerebral metabolic rate of oxygen (CMRO 2) is an important measure of brain function.
Since it is challenging to measure directly, especially dynamically, a number of …
Since it is challenging to measure directly, especially dynamically, a number of …
Develo** transmission line equations of oxygen transport for predicting oxygen distribution in the arterial system
The oxygen content in the arterial system plays a significant role in determining the
physiological status of a human body. Understanding the oxygen concentration distribution …
physiological status of a human body. Understanding the oxygen concentration distribution …
Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging
Background Tumor hypoxia is involved in every stage of solid tumor development: formation,
progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors—chronic …
progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors—chronic …