Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

Probiotics are used for both generally healthy consumers and in clinical settings. However,
theoretical and proven adverse events from probiotic consumption exist. New probiotic …

The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Inter-individual human variability, driven by various genetic and environmental factors,
complicates the ability to develop effective population-based early disease detection …

Surveillance of antibiotic resistance genes (ARGs) has been increasingly conducted in
environmental sectors to complement the surveys in human and animal sectors under the …

Highlights•AMR is a leading and constantly growing threat to global health.•The human
microbiome is an important AMR reservoir.•Human–animal–environment interactions favor …

Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is characterized as a chronic and recurrent inflammatory disease whose pathogenesis …

ABSTRACT A global rise in antimicrobial resistance among pathogenic bacteria has proved
to be a major public health threat, with the rate of multidrug-resistant bacterial infections …