Reinforcement amid genetic diversity in the Candida albicans biofilm regulatory network
Biofilms of the fungal pathogen Candida albicans include abundant long filaments called
hyphae. These cells express hypha-associated genes, which specify diverse virulence …
hyphae. These cells express hypha-associated genes, which specify diverse virulence …
The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance
Phenotypic heterogeneity in genetically clonal populations facilitates cellular adaptation to
adverse environmental conditions while enabling a return to the basal physiological state. It …
adverse environmental conditions while enabling a return to the basal physiological state. It …
Click synthesis of pyrrolidine-based 1, 2, 3-triazole derivatives as antifungal agents causing cell cycle arrest and apoptosis in Candida auris
The emergence of multidrug-resistant fungal pathogens such as Candida auris is one of the
major reasons WHO has declared fungal infections as a public health threat. Multidrug …
major reasons WHO has declared fungal infections as a public health threat. Multidrug …
Hgc1 independence of biofilm hyphae in Candida albicans
Biofilm and hypha formation are central to virulence of the fungal pathogen Candida
albicans. The G1 cyclin gene HGC1 is required for hypha formation under diverse in vitro …
albicans. The G1 cyclin gene HGC1 is required for hypha formation under diverse in vitro …
[HTML][HTML] Protective effects of peptide KSPLY derived from Hericium erinaceus on H2O2-induced oxidative damage in HepG2 cells
Reactive oxygen species (ROS)-induced oxidative damage is strongly associated with the
pathogenesis of chronic diseases, and natural antioxidant peptides have good abilities of …
pathogenesis of chronic diseases, and natural antioxidant peptides have good abilities of …
Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections
J Neves-da-Rocha, MJ Santos-Saboya, MER Lopes… - Microorganisms, 2023 - mdpi.com
Fungi are a diverse group of eukaryotic organisms that infect humans, animals, and plants.
To successfully colonize their hosts, pathogenic fungi must continuously adapt to the host's …
To successfully colonize their hosts, pathogenic fungi must continuously adapt to the host's …
Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence
The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …
impact on global health, causing 181,000 deaths annually. Current treatment options are …
Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans
Candida albicans is a leading human fungal pathogen, which can cause superficial
infections or life-threatening systemic disease in immunocompromised individuals. The …
infections or life-threatening systemic disease in immunocompromised individuals. The …
Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds
Candida albicans, an opportunistic human pathogen, poses a significant threat to human
health and is associated with significant socio-economic burden. Current antifungal …
health and is associated with significant socio-economic burden. Current antifungal …
The Snf5‐Hsf1 transcription module synergistically regulates stress responses and pathogenicity by maintaining ROS homeostasis in Sclerotinia sclerotiorum
K **ao, L Liu, R He, JA Rollins, A Li, G Zhang… - New …, 2024 - Wiley Online Library
The SWI/SNF complex is guided to the promoters of designated genes by its co‐operator to
activate transcription in a timely and appropriate manner to govern development …
activate transcription in a timely and appropriate manner to govern development …