Septic shock is a leading cause of hospitalisation, morbidity, and mortality for children
worldwide. In 2020, the paediatric Surviving Sepsis Campaign (SSC) issued evidence …

Introduction Pediatric and neonatal sepsis is one of the main causes of mortality and
morbidity in these age groups. Accurate and early etiological identification is essential for …

OBJECTIVES: To assess the disruption of endothelial glycocalyx integrity in children with
sepsis receiving fluid resuscitation with either balanced or unbalanced crystalloids. The …

The international sepsis guidelines emphasize the importance of early identification along
with the combined administration of fluids, antibiotics and vasopressors as essential steps in …

Background Sepsis is one of the main causes of morbidity and mortality worldwide. Fluid
resuscitation is among the most common interventions and is associated with fluid overload …

Backgrounds In children with sepsis, circulatory shock and multi-organ failure remain major
contributors to mortality. Prolonged capillary refill time (PCRT) is a clinical tool associated …

Background We assessed the outcomes and characteristics of culture-negative septic shock
(CNSS) and culture-positive septic shock (CPSS) in pediatric intensive care unit (PICU) …

Objective The renal angina index (RAI) provides a clinically feasible and applicable tool to
identify critically ill children at risk of severe acute kidney injury (AKI) in high-income …

Aims To compare early versus the delayed start of epinephrine administration after fluids
bolus in children with septic shock. Methods We conducted an open-label randomized trial …

Objective The objective of this study was to evaluate the association between serum
albumin levels and microcirculation changes, glycocalyx degradation, and the clinical …