Hierarchical materials from high information content macromolecular building blocks: construction, dynamic interventions, and prediction

L Shao, J Ma, JL Prelesnik, Y Zhou, M Nguyen… - Chemical …, 2022 - ACS Publications
Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature.
Because hierarchy gives rise to unique properties and functions, many have sought …

Computational design and manufacturing of sustainable materials through first-principles and materiomics

SC Shen, E Khare, NA Lee, MK Saad… - Chemical …, 2023 - ACS Publications
Engineered materials are ubiquitous throughout society and are critical to the development
of modern technology, yet many current material systems are inexorably tied to widespread …

Generative design of de novo proteins based on secondary-structure constraints using an attention-based diffusion model

B Ni, DL Kaplan, MJ Buehler - Chem, 2023 - cell.com
We report two generative deep-learning models that predict amino acid sequences and 3D
protein structures on the basis of secondary-structure design objectives via either the overall …

MeLM, a generative pretrained language modeling framework that solves forward and inverse mechanics problems

MJ Buehler - Journal of the Mechanics and Physics of Solids, 2023 - Elsevier
We report a flexible multi-modal mechanics language model, MeLM, applied to solve
various nonlinear forward and inverse problems, that can deal with a set of instructions …

Functionalized silk fibroin nanofibers as drug carriers: Advantages and challenges

M Farokhi, F Mottaghitalab, RL Reis… - Journal of Controlled …, 2020 - Elsevier
Electrospinning is well thought of as the most potent nanofiber producing technique, which
is applicable in biomedical fields. The generation of electrospun nanofibers as drug carriers …

Modeling and design of heterogeneous hierarchical bioinspired spider web structures using deep learning and additive manufacturing

W Lu, NA Lee, MJ Buehler - Proceedings of the National …, 2023 - National Acad Sciences
Spider webs are incredible biological structures, comprising thin but strong silk filament and
arranged into complex hierarchical architectures with striking mechanical properties (eg …

MechGPT, a Language-Based Strategy for Mechanics and Materials Modeling That Connects Knowledge Across Scales, Disciplines, and Modalities

MJ Buehler - Applied Mechanics Reviews, 2024 - asmedigitalcollection.asme.org
For centuries, researchers have sought out ways to connect disparate areas of knowledge.
While early scholars (Galileo, da Vinci, etc.) were experts across fields, specialization took …

Recent progress in materials chemistry to advance flexible bioelectronics in medicine

G Balakrishnan, J Song, C Mou… - Advanced …, 2022 - Wiley Online Library
Designing bioelectronic devices that seamlessly integrate with the human body is a
technological pursuit of great importance. Bioelectronic medical devices that reliably and …

ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model

B Ni, DL Kaplan, MJ Buehler - Science Advances, 2024 - science.org
Through evolution, nature has presented a set of remarkable protein materials, including
elastins, silks, keratins and collagens with superior mechanical performances that play …