Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
M Zoulikha, Q **ao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …
several unmet medical needs, including acute lung injury/acute respiratory distress …
[HTML][HTML] Nanomedicine for acute respiratory distress syndrome: the latest application, targeting strategy, and rational design
Q Qiao, X Liu, T Yang, K Cui, L Kong, C Yang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation
and destruction of the lung air–blood barrier, leading to irreversible and substantial …
and destruction of the lung air–blood barrier, leading to irreversible and substantial …
Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …
Advanced nanomedicines for the treatment of inflammatory diseases
Inflammation, a common feature of many diseases, is an essential immune response that
enables survival and maintains tissue homeostasis. However, in some conditions, the …
enables survival and maintains tissue homeostasis. However, in some conditions, the …
Recent advances in nanoparticle applications in respiratory disorders: a review
Various nanoparticles are used in the discovery of new nanomedicine to overcome the
shortages of conventional drugs. Therefore, this article presents a comprehensive and up-to …
shortages of conventional drugs. Therefore, this article presents a comprehensive and up-to …
Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome
C Zhuang, M Kang, M Lee - Journal of Controlled Release, 2023 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …
Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model
To improve the efficacy of nucleic acid-based therapeutics, eg, small interfering RNA
(siRNA), transfection agents are needed for efficient delivery into cells. Several classes of …
(siRNA), transfection agents are needed for efficient delivery into cells. Several classes of …
Nanotechnologies for intranasal drug delivery: an update of literature
R Lombardo, T Musumeci, C Carbone… - Pharmaceutical …, 2021 - Taylor & Francis
Scientific research has focused its attention on finding an alternative route to systemic oral
and parenteral administration, to overcome their usual drawbacks, such as hepatic first-pass …
and parenteral administration, to overcome their usual drawbacks, such as hepatic first-pass …