Antifibrotic agents for the management of CKD: a review
Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and a potential therapeutic
target. However, there are conceptual and practical challenges to directly targeting kidney …
target. However, there are conceptual and practical challenges to directly targeting kidney …
Klotho as potential autophagy regulator and therapeutic target
H Zhou, S Pu, H Zhou, Y Guo - Frontiers in Pharmacology, 2021 - frontiersin.org
The protein Klotho can significantly delay aging, so it has attracted widespread attention.
Abnormal downregulation of Klotho has been detected in several aging-related diseases …
Abnormal downregulation of Klotho has been detected in several aging-related diseases …
Association between serum Klotho levels and the prevalence of diabetes among adults in the United States
K Wang, Y Mao, M Lu, X Liu, Y Sun, Z Li, Y Li… - Frontiers in …, 2022 - frontiersin.org
Background Diabetes is a critical contributor to the pathogenesis of cardiovascular diseases.
Klotho is an anti− aging protein with cardiovascular-renal protective effects. However, the …
Klotho is an anti− aging protein with cardiovascular-renal protective effects. However, the …
Cellular senescence of renal tubular epithelial cells in renal fibrosis
JQ Zhang, YY Li, XY Zhang, ZH Tian, C Liu… - Frontiers in …, 2023 - frontiersin.org
Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney
diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the …
diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the …
Oxidative stress and cellular senescence are involved in the aging kidney
L Marquez-Exposito, L Tejedor-Santamaria… - Antioxidants, 2022 - mdpi.com
Chronic kidney disease (CKD) can be considered as a clinical model for premature aging.
However, non-invasive biomarkers to detect early kidney damage and the onset of a …
However, non-invasive biomarkers to detect early kidney damage and the onset of a …
Role of Chronic Kidney Disease (CKD)–Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD
S Yamada, T Nakano - Journal of atherosclerosis and thrombosis, 2023 - jstage.jst.go.jp
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney
disease (CKD). Multiple factors account for the increased incidence of cardiovascular …
disease (CKD). Multiple factors account for the increased incidence of cardiovascular …
[HTML][HTML] Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes
Q Li, M Wang, X Li, Y Shao - Experimental Gerontology, 2023 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness worldwide and a costly
complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR …
complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR …
The association between dietary fiber intake and serum klotho levels in americans: A cross-sectional study from the national health and nutrition examination survey
S Liu, M Wu, Y Wang, L **ang, G Luo, Q Lin, L **ao - Nutrients, 2023 - mdpi.com
Background: Klotho is an aging-related marker closely associated with a number of
diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can …
diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can …
Emerging role of α-Klotho in energy metabolism and cardiometabolic diseases
Y Liu, M Chen - Diabetes & Metabolic Syndrome: Clinical Research & …, 2023 - Elsevier
Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …
Mineralocorticoid receptor antagonist use in chronic kidney disease with type 2 diabetes: a clinical practice document by the European Renal Best Practice (ERBP) …
P Sarafidis, F Iatridi, C Ferro… - Clinical Kidney …, 2023 - academic.oup.com
Chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) represents a major
public health issue; it develops in about 30%–40% of patients with diabetes mellitus and is …
public health issue; it develops in about 30%–40% of patients with diabetes mellitus and is …