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Biology of lung macrophages in health and disease
Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting
Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …
Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy
In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the …
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the …
IL-6 ameliorates acute lung injury in influenza virus infection
Abstract Interleukin 6 (IL-6) is involved in innate and adaptive immune responses to defend
against pathogens. It also participates in the process of influenza infection by affecting viral …
against pathogens. It also participates in the process of influenza infection by affecting viral …
[HTML][HTML] Regulatory cytokine function in the respiratory tract
The respiratory tract is an important site of immune regulation; required to allow protective
immunity against pathogens, while minimizing tissue damage and avoiding aberrant …
immunity against pathogens, while minimizing tissue damage and avoiding aberrant …
COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts
The COVID‐19 pandemic rapidly spread around the world following the first reports in
Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is …
Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is …
After the storm: regeneration, repair, and reestablishment of homeostasis between the alveolar epithelium and innate immune system following viral lung injury
JD Planer, EE Morrisey - Annual Review of Pathology …, 2023 - annualreviews.org
The mammalian lung has an enormous environmental-epithelial interface that is optimized
to accomplish the principal function of the respiratory system, gas exchange. One …
to accomplish the principal function of the respiratory system, gas exchange. One …
Insights into the immuno-pathogenesis of acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is a clinical syndrome associated with
oxygenation failure resulting from a direct pulmonary or indirect systemic insult. It is a …
oxygenation failure resulting from a direct pulmonary or indirect systemic insult. It is a …
Controlling immunity and inflammation through integrin-dependent regulation of TGF-β
M Nolte, C Margadant - Trends in cell biology, 2020 - cell.com
Integrins promote cell adhesion and migration, but also control local activation of latent
transforming growth factor (TGF)-β contained in extracellular matrix or cell-surface …
transforming growth factor (TGF)-β contained in extracellular matrix or cell-surface …