Regulation, functions and transmission of bivalent chromatin during mammalian development

TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

[HTML][HTML] An ethical framework for human embryology with embryo models

NC Rivron, AM Arias, MF Pera, N Moris, HI M'hamdi - Cell, 2023 - cell.com
A human embryo's legal definition and its entitlement to protection vary greatly worldwide.
Recently, human pluripotent stem cells have been used to form in vitro models of early …

Embryo model completes gastrulation to neurulation and organogenesis

G Amadei, CE Handford, C Qiu, J De Jonghe… - Nature, 2022 - nature.com
Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in
vitro,,,–, but their developmental potential is substantially extended by interactions with …

[HTML][HTML] Complete human day 14 post-implantation embryo models from naive ES cells

B Oldak, E Wildschutz, V Bondarenko, MY Comar… - Nature, 2023 - nature.com
The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

[HTML][HTML] Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs

S Tarazi, A Aguilera-Castrejon, C Joubran, N Ghanem… - Cell, 2022 - cell.com
In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids

L Liu, S Oura, Z Markham, JN Hamilton, RM Skory, L Li… - Cell, 2023 - cell.com
In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Cynomolgus monkey embryo model captures gastrulation and early pregnancy

J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang… - Cell Stem Cell, 2023 - cell.com
Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

AA Pollen, U Kilik, CB Lowe, JG Camp - Nature Reviews Genetics, 2023 - nature.com
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

[HTML][HTML] Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development

KYC Lau, H Rubinstein, CW Gantner, R Hadas… - Cell Stem Cell, 2022 - cell.com
Several in vitro models have been developed to recapitulate mouse embryogenesis solely
from embryonic stem cells (ESCs). Despite mimicking many aspects of early development …

The specious art of single-cell genomics

T Chari, L Pachter - PLOS Computational Biology, 2023 - journals.plos.org
Dimensionality reduction is standard practice for filtering noise and identifying relevant
features in large-scale data analyses. In biology, single-cell genomics studies typically begin …