Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
[HTML][HTML] An ethical framework for human embryology with embryo models
A human embryo's legal definition and its entitlement to protection vary greatly worldwide.
Recently, human pluripotent stem cells have been used to form in vitro models of early …
Recently, human pluripotent stem cells have been used to form in vitro models of early …
Embryo model completes gastrulation to neurulation and organogenesis
Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in
vitro,,,–, but their developmental potential is substantially extended by interactions with …
vitro,,,–, but their developmental potential is substantially extended by interactions with …
[HTML][HTML] Complete human day 14 post-implantation embryo models from naive ES cells
The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …
and technical challenges associated with intrauterine development after implantation …
[HTML][HTML] Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs
In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …
Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids
In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
Cynomolgus monkey embryo model captures gastrulation and early pregnancy
J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang… - Cell Stem Cell, 2023 - cell.com
Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
[HTML][HTML] Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development
KYC Lau, H Rubinstein, CW Gantner, R Hadas… - Cell Stem Cell, 2022 - cell.com
Several in vitro models have been developed to recapitulate mouse embryogenesis solely
from embryonic stem cells (ESCs). Despite mimicking many aspects of early development …
from embryonic stem cells (ESCs). Despite mimicking many aspects of early development …
The specious art of single-cell genomics
Dimensionality reduction is standard practice for filtering noise and identifying relevant
features in large-scale data analyses. In biology, single-cell genomics studies typically begin …
features in large-scale data analyses. In biology, single-cell genomics studies typically begin …