The ability to apply controlled forces to individual molecules or molecular complexes and
observe their behaviors has led to many important discoveries in biology. Instruments …

Nucleic acid‐based molecular recognition plays crucial roles in various fields like
biosensing and disease diagnostics. To achieve optimal detection and analysis, it is …

Advances in molecular dynamics (MD) software alongside enhanced computational power
and hardware have allowed for MD simulations to significantly expand our knowledge of …

The DNA double helix structure is stabilized by base-pairing and base-stacking interactions.
However, a comprehensive understanding of dinucleotide base-stacking energetics is …

Molecular dynamics simulations can be used in combination with experimental techniques
to uncover the intricacies of biomolecular structure, dynamics, and the resulting interactions …

Multivalency as an interaction principle is widely utilized in nature. It enables specific and
strong binding by multiple weak interactions through enhanced avidity and is a core process …

MicroRNA (miRNA) dysregulation is closely related to the occurrence and progression of
medulloblastoma (MB). However, the full potential of serum circulating miRNAs in MB …

Regulatory modules for controlling the kinetics of toehold-mediated strand displacement
(TMSD) play critical roles in designing dynamic and dissipative DNA chemical reaction …

Multiple RNA strands can interact in solution and assume a large variety of configurations
dictated by their potential for base pairing. Although duplex formation from two …

Base stacking is crucial in nucleic acid stabilization, from DNA duplex hybridization to single-
stranded DNA (ssDNA) protein binding. While stacking energies are tiny in ssDNA, they are …