Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

In this review, we shall outline the basic principles Ž. of circular dichroism CD and indicate
the types of structural information relevant to the study of the Ž. folding and unfolding or …

The ability to regulate any protein of interest in living systems with small molecules remains
a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a …

Proteins have dynamic structures that undergo chain motions on time scales spanning from
picoseconds to seconds. Resolving the resultant conformational heterogeneity is essential …

The ability of protein molecules to fold into their highly structured functional states is one of
the most remarkable evolutionary achievements of biology. In recent years, our …

Intrinsically disordered proteins (IDPs) defy the structure–function paradigm as they fulfill
essential biological functions while lacking well‐defined secondary and tertiary structures …

▪ Abstract In order to solve the immensely difficult protein-folding problem, it will be
necessary to characterize the barriers that slow folding and the intermediate structures that …

Conspectus Assessment of protein structure and interaction is crucial for understanding
protein structure/function relationships. Compared to high-resolution structural tools …

The traditional view that partly folded intermediates are important for directing a protein
toward the native state has been challenged by the notion that proteins can intrinsically fold …

During and after protein translation, molecular chaperones require ATP hydrolysis to favor
the native folding of their substrates and, under stress, to avoid aggregation and revert …