Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives

P Pattanayak, SK Singh, M Gulati, S Vishwas… - Microfluidics and …, 2021 - Springer
Microfluidic chip technology is an emerging tool in the field of biomedical application.
Microfluidic chip includes a set of groves or microchannels that are engraved on different …

Miniaturizing chemistry and biology using droplets in open systems

Y Zeng, JW Khor, TL van Neel, W Tu… - Nature Reviews …, 2023 - nature.com
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in
an open environment. They combine the compartmentalization and control offered by …

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis

J Ko, J Ahn, S Kim, Y Lee, J Lee, D Park, NL Jeon - Lab on a Chip, 2019 - pubs.rsc.org
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …

Tuning the structure, conductivity, and wettability of laser-induced graphene for multiplexed open microfluidic environmental biosensing and energy storage devices

B Chen, ZT Johnson, D Sanborn, RG Hjort… - ACS …, 2021 - ACS Publications
The integration of microfluidics and electrochemical cells is at the forefront of emerging
sensors and energy systems; however, a fabrication scheme that can create both the …

Perfusable micro-vascularized 3D tissue array for high-throughput vascular phenotypic screening

J Yu, S Lee, J Song, SR Lee, S Kim, H Choi, H Kang… - Nano …, 2022 - Springer
Microfluidic organ-on-a-chip technologies have enabled construction of biomimetic
physiologically and pathologically relevant models. This paper describes an injection …

Open microfluidic capillary systems

E Berthier, AM Dostie, UN Lee, J Berthier… - Analytical …, 2019 - ACS Publications
Open microfluidic capillary systems are a rapidly evolving branch of microfluidics where
fluids are manipulated by capillary forces in channels lacking physical walls on all sides …

Bioinspired superwettable microspine chips with directional droplet transportation for biosensing

Y Chen, K Li, S Zhang, L Qin, S Deng, L Ge, LP Xu… - ACS …, 2020 - ACS Publications
Directional droplet transportation without extra energy input remains a challenge in
microfluidic biochips for clinical detections. Herein, inspired by the water-collecting …

Engineering organ-on-a-chip to accelerate translational research

J Ko, D Park, S Lee, B Gumuscu, NL Jeon - Micromachines, 2022 - mdpi.com
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …

Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling

J Yu, E Berthier, A Craig, TE de Groot… - Nature biomedical …, 2019 - nature.com
The study of intercellular signalling networks requires organotypic microscale systems that
facilitate the culture, conditioning and manipulation of cells. Here, we describe a …

Microfluidics within a well: an injection-molded plastic array 3D culture platform

Y Lee, JW Choi, J Yu, D Park, J Ha, K Son, S Lee… - Lab on a Chip, 2018 - pubs.rsc.org
Polydimethylsiloxane (PDMS) has been widely used in fabricating microfluidic devices for
prototy** and proof-of-concept experiments. Due to several material limitations, PDMS …