The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

Publisher Summary CD44 is a ubiquitous multistructural and multifunctional cell surface
adhesion molecule involved in cell–cell and cell–matrix interactions. CD44s is a single …

The CD44 proteins form a ubiquitously expressed family of cell surface adhesion molecules
involved in cell-cell and cell-matrix interactions. The multiple protein isoforms are encoded …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …

The CD44 molecule is known to display extensive size heterogeneity, which has been
attributed both to alternative splicing and to differential glycosylation within the extracellular …

Despite advances in new approaches for colorectal cancer (CRC) therapy, intravenous
chemotherapy remains one of the main treatment options; however, it has limitations …

Publisher Summary This chapter focuses on CD44 and its interaction with extracellular
matrix. CD44 is a broadly distributed family of cell surface glycoprotein that has been studied …

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-
related protein that functions as a tumor suppressor. We found that merlin mediates contact …

CD44 is a transmembrane glycoprotein, the variant isoforms of which are coded for by
alternative splicing, with the most prolific isoform being CD44 standard. CD44 is found in a …