Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

Cell adhesion is crucial for the assembly of individual cells into the three-dimensional
tissues of animals. Cells do not simply “stick” together to form tissues, but rather are …

Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The
dynamic regulation of cadherins in response to various extracellular signals controls cell …

The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ
fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops …

Integrin adhesion receptors play a crucial role in regulating interactions between cells and
extracellular matrix (ECM). Integrin activation initiates multiple intracellular signaling …

The circulatory and migratory properties of white blood cells have evolved to allow efficient
surveillance of tissues for infectious pathogens and rapid accumulation at sites of injury and …

The response of host organism in macroscopic, cellular and protein levels to biomaterials is,
in most cases, closely associated with the materials' surface properties. In tissue …