Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Tumor cells exhibit elevated levels of glucose uptake, a phenomenon that has been
capitalized upon for the prognostic and diagnostic imaging of a wide range of cancers using …

Autophagy is a type of cellular catabolic degradation response to nutrient starvation or
metabolic stress. The main function of autophagy is to maintain intracellular metabolic …

Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …

Autophagy is a basic catabolic process, serving as an internal engine during responses to
various cellular stresses. As regards cancer, autophagy may play a tumor suppressive role …

Autophagy, or cellular self-digestion, is activated in cancer cells in response to multiple
stresses and has been demonstrated to promote tumor cell survival and drug resistance …

Multiple myeloma is one of numerous malignancies characterized by increased glucose
consumption, a phenomenon with significant prognostic implications in this disease. Few …

Background: Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the
'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many …

Multiple myeloma (MM) remains an incurable haematological malignancy despite
substantial advances in therapy. Hypoxic bone marrow induces metabolic rewiring in MM …

Over the past two decades, the natural history of multiple myeloma (MM) has evolved
dramatically, owing primarily to novel agents targeting MM in the bone marrow …