Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Epidemiological and biological plausibility studies support a cause-and-effect relationship
between increased levels of physical activity or cardiorespiratory fitness and reduced …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Self‐care is essential in the long‐term management of chronic heart failure. Heart failure
guidelines stress the importance of patient education on treatment adherence, lifestyle …

High-Altitude Travel with Medical Problems Travel to high altitude is increasing. The authors
discuss physiological changes at high altitude, pretravel evaluation for common medical …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …

Millions of people visit high-altitude regions annually and more than 80 million live
permanently above 2,500 m. Acute high-altitude exposure can trigger high-altitude illnesses …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Guidelines summarize and evaluate available evidence with the aim of assisting health
professionals in selecting the best management strategies for an individual patient with a …

Abstract Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo
Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers …