Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomes are the main organelles in macrophages for killing invading bacteria. However,
the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …

The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental
and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic …

Increased macroautophagy/autophagy and lysosomal activity promote tumor growth,
survival and chemo-resistance. During acute starvation, autophagy is rapidly engaged by …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …

Response and adaptation to stress are critical for the survival of all living organisms. The
regulation of the transcriptional machinery is an important aspect of these complex …

Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …

Old age is associated with a greater burden of disease, including neurodegenerative
disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic …