The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …

DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …

This is the first book to collate and synthesize the recent burgeoning primary research
literature on dog behaviour, evolution, and cognition. The author presents a new ecological …

Improved understanding of longevity represents a significant welfare opportunity for the
domestic dog, given its unparalleled morphological diversity. Epidemiological research …

Background: Anecdotal beliefs and limited research suggest variable patterns of mortality in
age, size, and breed cohorts of dogs. Detailed knowledge of mortality patterns would …

Rather than being a passive, haphazard process of wear and tear, lifespan can be
modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in …

In this prospective study, a canine-adapted histological grading method was compared with
histopathological and clinical characteristics and was evaluated as a prognostic indicator in …

The guidelines are an update and extension of the AAHA Canine Life Stage Guidelines
published in 2012. A noteworthy change from the earlier guidelines is the division of the …

Large body size is one of the best predictors of long life span across species of mammals. In
marked contrast, there is considerable evidence that, within species, larger individuals are …