MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Various diseases, including cancers, age-associated disorders, and acute liver failure, have
been linked to the oncogene, MYC. Animal testing and clinical trials have shown that …

The MYC oncogene is upregulated in human cancers by translocation, amplification, and
mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box …

Studies of the regulation of nucleolar function are critical for ascertaining clearer insights into
the basic biological underpinnings of ribosome biogenesis (RB), and for future development …

MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and
protein translation. Here, we show that MYC-induced protein translation is mediated by the …

Protein engineering has emerged as a powerful approach toward the development of novel
therapeutics targeting the MYC/MAX/E-box network, an active driver of> 70% of cancers …

Myc, a transcription factor with oncogenic activity, is upregulated by amplification,
translocation, and mutation of the cellular pathways that regulate its stability. Inhibition of the …

The effect of targeted therapeutics on anticancer immune responses is poorly understood.
The BRAF inhibitor dabrafenib has been reported to activate the integrated stress response …

Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the
survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting …

Among the first discovered and most prominent cellular oncogenes is MYC, which encodes
a bHLH-ZIP transcription factor (Myc) that both activates and suppresses numerous genes …