FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Circular RNA and miR-7 in cancer

TB Hansen, J Kjems, CK Damgaard - Cancer research, 2013 - AACR
MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often
deregulated in cancer. The identification of competing endogenous RNA and circular RNA …

Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

D Hanniford, A Ulloa-Morales, A Karz… - Cancer cell, 2020 - cell.com
Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms
governing metastatic spread may uncover important tumor biology and/or yield promising …

FAK in cancer: from mechanisms to therapeutic strategies

HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

The role of microRNAs in inflammation

K Das, LVM Rao - International Journal of Molecular Sciences, 2022 - mdpi.com
Inflammation is a biological response of the immune system to various insults, such as
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …

[HTML][HTML] Circular RNAs in cancer: novel insights into origins, properties, functions and implications

J Li, J Yang, P Zhou, Y Le, C Zhou, S Wang… - American journal of …, 2015 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are a large class of RNAs that, unlike linear RNAs, form covalently
closed continuous loops and have recently shown huge capabilities as gene regulators in …

MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway

H Zhang, K Cai, J Wang, X Wang, K Cheng, F Shi… - Stem …, 2014 - academic.oup.com
Epithelial–mesenchymal transition (EMT) contributes to tumor invasion and metastasis in
many cancers and correlates highly with the acquisition of cancer stem cell (CSC) …

MicroRNAs contribute to breast cancer invasiveness

I Fridrichova, I Zmetakova - Cells, 2019 - mdpi.com
Cancer statistics in 2018 highlight an 8.6 million incidence in female cancers, and 4.2 million
cancer deaths globally. Moreover, breast cancer is the most frequent malignancy in females …

Circular RNAs and cancer

J He, Q **e, H Xu, J Li, Y Li - Cancer letters, 2017 - Elsevier
Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5′-terminal
cap and 3′-terminal poly A tail. A large number of circRNAs have been identified through …

MiR-7-5p suppresses tumor metastasis of non-small cell lung cancer by targeting NOVA2

H **ao - Cellular & Molecular Biology Letters, 2019 - Springer
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality
worldwide. Distant metastasis is thought to be one of the most important factors responsible …