The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Our ability to manipulate the genetic constitution of the nervous system has come of age with
various technologies, including virus vectors that can efficiently deliver genes to neurons …

Many currently incurable forms of blindness affecting the retina have a genetic etiology and
several others, such as those resulting from retinal vascular disturbances, respond to …

Purpose. To investigate the role of vitreous in nonviral gene delivery into retinal pigment
epithelial (RPE) cells. Methods. Human RPE cell line D407 was cultured in six-well plates …

A wide range of retinal disorders can potentially be treated using viral vector-mediated gene
therapy. The most widely used vectors for ocular gene delivery are based on adeno …

Glaucoma is a complex group of optic neuropathies that affects both humans and animals.
Intraocular pressure (IOP) elevation is a major risk factor that results in the loss of retinal …

Normal visual function in humans is compromised by a range of inherited and acquired
degenerative conditions, many of which affect photoreceptors and/or retinal pigment …

Corneal disease remains a leading cause of impaired vision world-wide, and advancements
in gene therapy continue to develop with promising success to prevent, treat and cure …

Biologics, like peptides, proteins and nucleic acids, have proven to be promising drugs for
the treatment of numerous diseases. However, besides the off label use of the monoclonal …

Introduction: Ocular hypertension in open-angle glaucoma is caused by a reduced rate of
removal of aqueous humour (AH) from the eye, with the majority of AH draining from the …