Advances in copper complexes as anticancer agents
Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …
Endoplasmic reticulum stress: an arising target for metal-based anticancer agents
AP King, JJ Wilson - Chemical Society Reviews, 2020 - pubs.rsc.org
The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …
Recent researches in triazole compounds as medicinal drugs
C -H. Zhou, Y Wang - Current medicinal chemistry, 2012 - benthamdirect.com
Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …
ring are readily able to bind with a variety of enzymes and receptors in biological system via …
Triazoles and tetrazoles: Prime ligands to generate remarkable coordination materials
The current great interest in preparing functional metal-organic materials is inevitably
associated with tremendous research efforts dedicated to the design and synthesis of new …
associated with tremendous research efforts dedicated to the design and synthesis of new …
Copper in diseases and treatments, and copper‐based anticancer strategies
Copper is found in all living organisms and is a crucial trace element in redox chemistry,
growth and development. It is important for the function of several enzymes and proteins …
growth and development. It is important for the function of several enzymes and proteins …
Copper complexes as anticancer agents
Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …
Biomedical applications of copper ionophores
V Oliveri - Coordination Chemistry Reviews, 2020 - Elsevier
Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
Recent developments on 1, 2, 4-triazole nucleus in anticancer compounds: a review
1, 2, 4-triazole is an important nucleus present in a large number of compounds. More than
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …
Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells
We report a quantitative structure− activity relationship study of a new class of pyrazole-
pyridine copper complexes that establishes a clear correlation between the ability to …
pyridine copper complexes that establishes a clear correlation between the ability to …
Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation
This study reports the structure–activity relationship of a series of 8-hydroxoquinoline
derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) …
derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) …