Advances and roadblocks in the treatment of malaria

B Hanboonkunupakarn, NJ White - British journal of clinical …, 2022 - Wiley Online Library
The deployment of artesunate for severe malaria and the artemisinin combination therapies
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …

Treatment and prevention of malaria in children

EA Ashley, JR Poespoprodjo - The Lancet Child & Adolescent …, 2020 - thelancet.com
Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …

Malaria in 2022: Increasing challenges, cautious optimism

P Jagannathan, A Kakuru - Nature communications, 2022 - nature.com
Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

MSF Soon, HJ Lee, JA Engel, J Straube… - Nature …, 2020 - nature.com
The dynamics of CD4+ T cell memory development remain to be examined at genome
scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its …

Resurgent and delayed malaria

B Greenwood, I Zongo, A Dicko, D Chandramohan… - Malaria Journal, 2022 - Springer
The populations of moderate or highly malaria endemic areas gradually acquire some
immunity to malaria as a result of repeated exposure to the infection. When this exposure is …

The regulation of CD4+ T cells during malaria

R Kumar, JR Loughland, SS Ng, MJ Boyle… - Immunological …, 2020 - Wiley Online Library
Malaria is a major global health problem. Despite decades of research, there is still no
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …

Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

E Wallender, AM Ali, E Hughes, A Kakuru… - Nature …, 2021 - nature.com
Intermittent preventive treatment (IPT) with dihydroartemisinin-piperaquine (DP) is highly
protective against malaria in children, but is not standard in malaria-endemic countries …

Weekly dihydroartemisinin–piperaquine versus monthly sulfadoxine–pyrimethamine for malaria chemoprevention in children with sickle cell anaemia in Uganda and …

R Idro, T Nkosi-Gondwe, R Opoka… - The Lancet Infectious …, 2024 - thelancet.com
Summary Background In many sub-Saharan African countries, it is recommended that
children with sickle cell anaemia receive malaria chemoprevention with monthly sulfadoxine …

Dihydroartemisinin protects blood–brain barrier permeability during sepsis by inhibiting the transcription factor SNAI1

F Liu, J Liu, H **ang, Z Sun, Y Li, X Li… - Clinical and …, 2022 - Wiley Online Library
Blood–brain barrier (BBB) injury is involved in the pathogenesis of sepsis‐associated
encephalopathy. In this study, we used dihydroartemisinin (DHA), a derivative of artemisinin …