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Advances and roadblocks in the treatment of malaria
B Hanboonkunupakarn, NJ White - British journal of clinical …, 2022 - Wiley Online Library
The deployment of artesunate for severe malaria and the artemisinin combination therapies
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …
Treatment and prevention of malaria in children
EA Ashley, JR Poespoprodjo - The Lancet Child & Adolescent …, 2020 - thelancet.com
Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …
Malaria in 2022: Increasing challenges, cautious optimism
Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …
though recent developments inspire optimism. This includes the approval of the world's first …
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory
The dynamics of CD4+ T cell memory development remain to be examined at genome
scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its …
scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its …
Resurgent and delayed malaria
B Greenwood, I Zongo, A Dicko, D Chandramohan… - Malaria Journal, 2022 - Springer
The populations of moderate or highly malaria endemic areas gradually acquire some
immunity to malaria as a result of repeated exposure to the infection. When this exposure is …
immunity to malaria as a result of repeated exposure to the infection. When this exposure is …
The regulation of CD4+ T cells during malaria
Malaria is a major global health problem. Despite decades of research, there is still no
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
Intermittent preventive treatment (IPT) with dihydroartemisinin-piperaquine (DP) is highly
protective against malaria in children, but is not standard in malaria-endemic countries …
protective against malaria in children, but is not standard in malaria-endemic countries …
Weekly dihydroartemisinin–piperaquine versus monthly sulfadoxine–pyrimethamine for malaria chemoprevention in children with sickle cell anaemia in Uganda and …
Summary Background In many sub-Saharan African countries, it is recommended that
children with sickle cell anaemia receive malaria chemoprevention with monthly sulfadoxine …
children with sickle cell anaemia receive malaria chemoprevention with monthly sulfadoxine …
Effect of malaria and malaria chemoprevention regimens in pregnancy and childhood on neurodevelopmental and behavioral outcomes in children at 12, 24, and 36 …
Background Malaria in pregnancy has been associated with worse cognitive outcomes in
children, but its association with behavioral outcomes and the effectiveness of malaria …
children, but its association with behavioral outcomes and the effectiveness of malaria …
Dihydroartemisinin protects blood–brain barrier permeability during sepsis by inhibiting the transcription factor SNAI1
F Liu, J Liu, H **ang, Z Sun, Y Li, X Li… - Clinical and …, 2022 - Wiley Online Library
Blood–brain barrier (BBB) injury is involved in the pathogenesis of sepsis‐associated
encephalopathy. In this study, we used dihydroartemisinin (DHA), a derivative of artemisinin …
encephalopathy. In this study, we used dihydroartemisinin (DHA), a derivative of artemisinin …