Progress in develo** inhibitors of SARS-CoV-2 3C-like protease
Q Li, CB Kang - Microorganisms, 2020 - mdpi.com
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The viral outbreak started in late 2019 and rapidly became a …
coronavirus 2 (SARS-CoV-2). The viral outbreak started in late 2019 and rapidly became a …
Mechanisms of action for small molecules revealed by structural biology in drug discovery
Q Li, CB Kang - International journal of molecular sciences, 2020 - mdpi.com
Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins. These compounds have a low molecular weight, making them penetrate …
important proteins. These compounds have a low molecular weight, making them penetrate …
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …
The evolution of Zika virus from Asia to the Americas
Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …
Molecular insights into the flavivirus replication complex
K Van den Elsen, JP Quek, D Luo - Viruses, 2021 - mdpi.com
Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …
Flavivirus nonstructural proteins and replication complexes as antiviral drug targets
Highlights•Molecular structures and predicated models of flaviviral NS proteins.•Recent
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …
Drugs for the treatment of Zika virus infection
JA Bernatchez, LT Tran, J Li, Y Luan… - Journal of medicinal …, 2019 - ACS Publications
Zika virus is an emerging flavivirus that causes the neurodevelopmental congenital Zika
syndrome and that has been linked to the neuroinflammatory Guillain–Barré syndrome. The …
syndrome and that has been linked to the neuroinflammatory Guillain–Barré syndrome. The …
Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease
Flaviviruses, including dengue, West Nile and recently emerged Zika virus, are important
human pathogens, but there are no drugs to prevent or treat these viral infections. The highly …
human pathogens, but there are no drugs to prevent or treat these viral infections. The highly …
[HTML][HTML] A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity
Zika virus (ZIKV) and dengue virus (DENV) are arthropod-borne pathogenic flaviviruses that
co-circulate in many countries. To understand some of the pressures that influence ZIKV …
co-circulate in many countries. To understand some of the pressures that influence ZIKV …
Structural biology of the Zika virus
Y Shi, GF Gao - Trends in biochemical sciences, 2017 - cell.com
Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes, has
emerged as a major health concern. ZIKV infections can cause serious neurological …
emerged as a major health concern. ZIKV infections can cause serious neurological …