Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

Myosin-driven contraction of the actin cytoskeleton is at the base of cell and tissue
morphogenesis. At the molecular level, myosin motors drive contraction by sliding actin …

Cells have evolved multiple mechanisms to apprehend and adapt finely to their
environment. Here we report a new cellular ability, which we term “curvotaxis” that enables …

The adult mammalian intestine is composed of two connected structures, the absorptive villi
and the crypts, which house progenitor cells. Mouse crypts develop postnatally and are the …

The actomyosin cytoskeleton is responsible for most force-driven processes in cells and
tissues. How it assembles into the necessary structures at the right time and place is an …

Highlights•Collective migration relies on the ability of a multicellular co-ordinated unit to
efficiently respond to physical changes in their surrounding matrix.•Conversely, migrating …

The discovery of general principles underlying the complexity and diversity of cellular and
developmental systems is a central and long-standing aim of biology. While new …

The axon initial segment (AIS) is the site of action potential generation and a locus of activity-
dependent homeostatic plasticity. A multimeric complex of sodium channels, linked via a …

Basal stem cells fuel development, homeostasis, and regeneration of the epidermis. The
proliferation and fate decisions of these cells are highly regulated by their microenvironment …

Cytoskeletal networks of actin filaments and myosin motors drive many dynamic cell
processes. A key characteristic of these networks is their contractility. Despite intense …