Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
JJ Chiu, S Chien - Physiological reviews, 2011 - journals.physiology.org
Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …
functions and vascular biology/pathobiology in health and disease. The flow patterns and …
Mammalian Krüppel-like factors in health and diseases
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …
processes that include proliferation, differentiation, growth, development, survival, and …
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
This protocol describes a simple but robust microfluidic assay combining three-dimensional
(3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel …
(3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
Organs-on-a-chip: a focus on compartmentalized microdevices
Advances in microengineering technologies have enabled a variety of insights into
biomedical sciences that would not have been possible with conventional techniques …
biomedical sciences that would not have been possible with conventional techniques …
Macro-and microscale fluid flow systems for endothelial cell biology
Recent advances in microfluidics have brought forth new tools for studying flow-induced
effects on mammalian cells, with important applications in cardiovascular, bone and cancer …
effects on mammalian cells, with important applications in cardiovascular, bone and cancer …
Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding
Vascular smooth muscle cells (VSMCs) have critical functions in vascular diseases.
Haemodynamic factors are important regulators of VSMC functions in vascular …
Haemodynamic factors are important regulators of VSMC functions in vascular …
In vivo modulation of endothelial polarization by Apelin receptor signalling
Endothelial cells (ECs) respond to shear stress by aligning in the direction of flow. However,
how ECs respond to flow in complex in vivo environments is less clear. Here we describe an …
how ECs respond to flow in complex in vivo environments is less clear. Here we describe an …
In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients
Sprouting angiogenesis requires a coordinated guidance from a variety of angiogenic
factors. Here, we have developed a unique hydrogel incorporating microfluidic platform …
factors. Here, we have developed a unique hydrogel incorporating microfluidic platform …
Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions: Sixth International Bio-Fluid Mechanics Symposium and Workshop …
Recent advances in microfluidic technologies have opened the door for creating more
realistic in vitro cell culture methods that replicate many aspects of the true in vivo …
realistic in vitro cell culture methods that replicate many aspects of the true in vivo …