Molecular mechanisms of circular RNA translation

HJ Hwang, YK Kim - Experimental & molecular medicine, 2024 - nature.com
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs without a 5′ cap
structure and a 3′ poly (A) tail typically present in linear mRNAs of eukaryotic cells …

[HTML][HTML] A day in the life of the exon junction complex

LP Schlautmann, NH Gehring - Biomolecules, 2020 - mdpi.com
The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP)
component that is assembled during splicing and binds to mRNAs upstream of exon-exon …

Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex

OH Park, H Ha, Y Lee, SH Boo, DH Kwon, HK Song… - Molecular cell, 2019 - cell.com
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in RNAs
and plays regulatory roles in a variety of biological and physiological processes. Despite its …

Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer

S Roy, M Kanda, S Nomura, Z Zhu, Y Toiyama… - Molecular Cancer, 2022 - Springer
Background Majority of gastric cancers (GC) are diagnosed at advanced stages which
contributes towards their poor prognosis. In view of this clinical challenge, identification of …

A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

D Kim, S Kim, J Park, HR Chang, J Chang… - Nature …, 2021 - nature.com
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which infected> 200 million people resulting in> 4 million deaths. However, temporal …

UPF1 promotes rapid degradation of m6A-containing RNAs

SH Boo, H Ha, Y Lee, MK Shin, S Lee, YK Kim - Cell reports, 2022 - cell.com
Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification in
eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m 6 A …

Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences

D Bergeron, L Faucher-Giguère, AK Emmerichs… - Genome Biology, 2023 - Springer
Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …

EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway

Y Liu, J Song, H Zhang, Z Liao, F Liu, C Su… - Journal of Experimental …, 2022 - Springer
Abstract Background Circular RNAs (circRNAs) function as crucial regulators in multiple
cancers, including hepatocellular carcinoma (HCC). However, the roles of circRNAs in HCC …

The branched nature of the nonsense-mediated mRNA decay pathway

Z Yi, M Sanjeev, G Singh - Trends in Genetics, 2021 - cell.com
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …

Stress granule: A promising target for cancer treatment

X Gao, L Jiang, Y Gong, X Chen, M Ying… - British journal of …, 2019 - Wiley Online Library
Stress granules (SGs) are primarily composed of mRNAs that stall at translation initiation
and usually appear in the cytoplasm under unusual physiological or pathological conditions …