Molecular mechanisms of circular RNA translation
HJ Hwang, YK Kim - Experimental & molecular medicine, 2024 - nature.com
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs without a 5′ cap
structure and a 3′ poly (A) tail typically present in linear mRNAs of eukaryotic cells …
structure and a 3′ poly (A) tail typically present in linear mRNAs of eukaryotic cells …
[HTML][HTML] A day in the life of the exon junction complex
LP Schlautmann, NH Gehring - Biomolecules, 2020 - mdpi.com
The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP)
component that is assembled during splicing and binds to mRNAs upstream of exon-exon …
component that is assembled during splicing and binds to mRNAs upstream of exon-exon …
Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in RNAs
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer
Background Majority of gastric cancers (GC) are diagnosed at advanced stages which
contributes towards their poor prognosis. In view of this clinical challenge, identification of …
contributes towards their poor prognosis. In view of this clinical challenge, identification of …
A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which infected> 200 million people resulting in> 4 million deaths. However, temporal …
which infected> 200 million people resulting in> 4 million deaths. However, temporal …
UPF1 promotes rapid degradation of m6A-containing RNAs
Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification in
eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m 6 A …
eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m 6 A …
Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences
D Bergeron, L Faucher-Giguère, AK Emmerichs… - Genome Biology, 2023 - Springer
Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …
EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway
Y Liu, J Song, H Zhang, Z Liao, F Liu, C Su… - Journal of Experimental …, 2022 - Springer
Abstract Background Circular RNAs (circRNAs) function as crucial regulators in multiple
cancers, including hepatocellular carcinoma (HCC). However, the roles of circRNAs in HCC …
cancers, including hepatocellular carcinoma (HCC). However, the roles of circRNAs in HCC …
The branched nature of the nonsense-mediated mRNA decay pathway
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …
Stress granule: A promising target for cancer treatment
X Gao, L Jiang, Y Gong, X Chen, M Ying… - British journal of …, 2019 - Wiley Online Library
Stress granules (SGs) are primarily composed of mRNAs that stall at translation initiation
and usually appear in the cytoplasm under unusual physiological or pathological conditions …
and usually appear in the cytoplasm under unusual physiological or pathological conditions …