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Glutathione and infection
BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
NADPH-dependent and-independent disulfide reductase systems
Over the past seven decades, research on autotrophic and heterotrophic model organisms
has defined how the flow of electrons (“reducing power”) from high-energy inorganic …
has defined how the flow of electrons (“reducing power”) from high-energy inorganic …
Low-molecular-mass antioxidants in parasites
RL Krauth-Siegel, AE Leroux - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …
Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases
BACKGROUND: There are two, largely autonomous antioxidant pathways in many
organisms, one based on thioredoxin and one based on glutathione, with each pathway …
organisms, one based on thioredoxin and one based on glutathione, with each pathway …
Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites
Significance: Platyhelminth parasites cause chronic infections that are a major cause of
disability, mortality, and economic losses in develo** countries. Maintaining redox …
disability, mortality, and economic losses in develo** countries. Maintaining redox …
Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum
LJ Song, JH Li, SY ** the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography
F Angelucci, D Dimastrogiovanni, G Boumis… - Journal of Biological …, 2010 - jbc.org
Schistosomiasis is the second most widespread human parasitic disease. It is principally
treated with one drug, praziquantel, that is administered to 100 million people each year; …
treated with one drug, praziquantel, that is administered to 100 million people each year; …
G6PDH as a key immunometabolic and redox trigger in arthropods
B Moraes, R Martins, C Lopes, R Martins… - Frontiers in …, 2023 - frontiersin.org
The enzyme glucose-6-phosphate dehydrogenase (G6PDH) plays crucial roles in glucose
homeostasis and the pentose phosphate pathway (PPP), being also involved in redox …
homeostasis and the pentose phosphate pathway (PPP), being also involved in redox …
Effects of mammalian thioredoxin reductase inhibitors
ESJ Arnér - Reactive Oxygen Species: Network Pharmacology and …, 2021 - Springer
The mammalian thioredoxin system is driven by NADPH through the activities of isoforms of
the selenoprotein thioredoxin reductase (TXNRD, TrxR), which in turn help to keep …
the selenoprotein thioredoxin reductase (TXNRD, TrxR), which in turn help to keep …
Antiparasitic effects of selected isoflavones on flatworms
D Faixová, G Hrčková, TM Kubašková… - …, 2021 - pmc.ncbi.nlm.nih.gov
Medicinal plants have been successfully used in the ethno medicine for a wide range of
diseases since ancient times. The research on natural products has allowed the discovery of …
diseases since ancient times. The research on natural products has allowed the discovery of …